Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. Pharmacy on Demand is a multi-disciplinary initiative created to realize the end-to-end continuous manufacturing of multiple Active Pharmaceutical Ingredients (API) in one mobile reconfigurable unit. By leveraging the advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation the group have been successful in creating a portfolio of drugs capable of production through end-to-end continuous manufacturing. Current efforts are focused on the design, construction and deployment of a unit that can successfully undergo an FDA submission which will potentially enable the final oral solid doses produced by the unit to be administered to patients.
Adamo et al., “On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system,” Science. 352, 61-67 (2016).