Luke Rogers

Postdoctoral Associate
Department of Chemical Engineering
Massachusetts Institute of Technology
77 Massachusetts Avenue, Building 66-507
Cambridge, MA  02139-4307
Phone: (617) 324-1896 | Fax: (617) 258-8992

Ph.D., Organic Medicinal Chemistry of Tetrapyrroles, Trinity College Dublin, Ireland, 2015
B.A. (mod.), Medicinal Chemistry, Trinity College Dublin, Ireland, 2010

Research Area:
Development of end-to-end continuous flow manufacturing of API.

Selected Publications:
Synthesis and biological evaluation of Foscan® bile acid conjugates to target esophageal cancer cells, Rogers, Luke; Majer, Ferenc; Sergeeva, Natalia N.; Paszko, Edyta; Gilmer, John F.; Senge, Mathias O. Bioorg. Med. Chem. Lett. 2013.

The Translocator Protein (TSPO, 18kDa) as a Potential Molecular Target for Improved Treatment Efficacy in Photodynamic Therapy. Rogers, Luke; Senge, Mathias O., Future Med. Chem. 6(7), 2014, 775-792 .

Simple Porphyrin Desymmetrization: mTHPP as a Gateway Molecule for Peripheral Functionalization. Rogers, Luke; Burke-Murphy, Emeralda; Senge, Mathias O., Eur. J. Org. Them 2014 (20) 4283-4294..

iPorphyrins: Temoporfin anti-inflammatory conjugates to target the esophageal tumor microenvironment for in vitro PDT. Plos One, 2015.
Preparation of Tri- and Hexasubstituted Triptycene Synthons by Transition Metal Catalysed Cross-Coupling Reactions for Post-Modifications, Moylan, Claire; Rogers, Luke; Shaker, Yasser M.; Davis, Mia; Eckhardt, Hans-Georg; Eckert, Raphael; Ryan, Aoife A.; Senge, Mathias O., Eur. J. Org. Chem, 1, 2016, 185-195.