Publications: 2011 – 2019

2019 (Recent)

2019

C.W. Coley, D.A. Thomas III, J.A. M. Lummiss, J.N. Jaworski, C.P. Breen, V. Schultz, T. Hart, J.S. Fishman, L. Rogers, H. Gao, R.W. Hicklin, P. P. Plehiers, J. Byington, J. S. Piotti, W.H. Green, A. J. Hart, T.F. Jamison, K.F. Jensen,  “A robotic platform for flow synthesis of organic compounds informed by AI planning,” Science, 365, 1-9 (2019)

K. Yang, K. Swanson, W. Jin, C. Coley, P. Eiden, H. Gao, A. Guzman-Perez, T. Hopper, B. Kelley, M. Mathea, A. Palmer, V. Settels, T. Jaakkola, K. Jensen, R. Barzilay,  “Analyzing Learned Molecular Representations for Property Prediction,” Journal of Chemical Information and Modeling, 59, 3370-3388 (2019)

L.M. Baumgartner, J.M. Dennis, N. A. White, S. L. Buchwald, K.F. Jensen,  “Use of a Droplet Platform To Optimize Pd-Catalyzed C–N Coupling Reactions Promoted by Organic Bases,” Organic Process Research & Development, 23, 1594-1601 (2019)

C.W. Coley, W.H. Green, K.F. Jensen,  “RDChiral: An RDKit Wrapper for Handling Stereochemistry in Retrosynthetic Template Extraction and Application,” Journal of Chemical Information and Modeling, 59, 2529-2537 (2019)

J. ZhangA.R. Teixeira, H. Zhang, and K.F. Jensen,  “Flow Toolkit for Measuring Gas Diffusivity in Liquids,” Analytical Chemistry, 91, 4004–4009 (2019)

L. YangA. Ładosz and K.F. Jensen,  “Analysis and simulation of multiphase hydrodynamics in capillary microseparators,” Lab on a Chip, 19, 706-715 (2019)

G. GiriL. YangY. Mo, and K.F. Jensen,  “Adding Crystals To Minimize Clogging in Continuous Flow Synthesis,” Crystal Growth Design, 19, 98-105 (2019)

C.W. ColeyW. JinL. Rogers,  T.F. JamisonT.S. JaakkolaW.H. GreenR. Barzilay, and K.F. Jensen, “A graph-convolutional neural network model for the prediction of chemical reactivity,” Chemical Science, 10, 370-377 (2019)

2018

2018

H. GaoT.J. StrubleC.W. ColeyY. WangW.H. Green, and K.F. Jensen, “Using Machine Learning To Predict Suitable Conditions for Organic Reactions,” ACS Central Science11, 1465-1476 (2018)

AC BédardA. AdamoK.C. Aroh, M.G. RussellA.A. BedermannJ. TorosianB. YueK.F. JensenT.F. Jamison, “Reconfigurable system for automated optimization of diverse chemical reactions,” Science, 361, 1220-1225 (2018)

M. P. StewartR. Langer, and K.F. Jensen,  “Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts,” Chem. Rev.118 (16), 7409–7531 (2018)

S.C.Born, Chelsea E.R.Edwards, B. Martin, K.F.Jensen, “Continuous, on-demand generation and separation of diphenylphosphoryl azide,” Tetrahedron743137-3142 (2018)

J. Baek, Y. Shen, I. Lignos, M.G. Bawendi, K.F. Jensen, “Multistage Microfluidic Platform for the Continuous Synthesis of III–V Core/Shell Quantum Dots,” Angew. Chem. DOI:10.1002/ange.201805264

L.M. Baumgartner, C.W. Coley, B.J. Reizman, K.W. Gaoab, K.F. Jensen, “Optimum catalyst selection over continuous and discrete process variables with a single droplet microfluidic reaction platform,” React. Chem. Eng., 3, 301-311 (2018) DOI:10.1039/C8RE00032H

C.W. Coley, W.H. Green, K.F. Jensen “Machine Learning in Computer-Aided Synthesis Planning,” Acc. Chem. Res., 51 (5), 1281-1289 (2018) DOI: 10.1021/acs.accounts.8b00087

Y.Mo, K.F. Jensen, “Continuous N‐Hydroxyphthalimide (NHPI)‐Mediated Electrochemical Aerobic Oxidation of Benzylic C−H Bonds,” Chem. Eur. J., 24 (40), 10260-10265 (2018) DOI:10.1002/chem.201802588

Y.Mo, H. Lin, K.F. Jensen, “High-performance miniature CSTR for biphasic C–C bond-forming reactions,” Chem. Eng. J., 335, 936-944 (2018) DOI:10.1016/j.cej.2017.10.114

HW Hsieh, C.W. Coley, L.M. Baumgartner, Klavs F. Jensen, and Richard I. Robinson, “Photoredox Iridium–Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor,” Org. Process Res. Dev., 22 (4), 542-550 (2018) DOI: 10.1021/acs.oprd.8b00018

P. Zhang, N. Weeranoppanant, D.A. Thomas, K. Tahara, T. Stelzer, M.G. Russell, M. O’Mahony, A.S. Myerson, H. Lin, L.P. Kelly, K.F. Jensen, T.F. Jamison, C. Dai, Y. Cui, N. Briggs, R.L. Beingessner, A. Adamo, “Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing,” Chem. Eur. J., 24, 2776 (2018) DOI:10.1002/chem.201706004

S. Lazzari, P.M. Theiler, Y. Shen, C.W. Coley, A. Stemmer, K.F. Jensen, “Ligand-Mediated Nanocrystal Growth,” Langmuir, 34 (10), 3307-3315 (2018) DOI: 10.1021/acs.langmuir.8b00076

C.W. Coley, L. Rogers, W.H. Green, K.F. Jensen, “SCScore: Synthetic Complexity Learned from a Reaction Corpus,” J. Chem. Inf. Model. , 58 (2), 252-261 (2018) DOI: 10.1021/acs.jcim.7b00622

Y. Mo, J. Imbrogno, H. Zhang, K.F. Jensen, “Scalable Thin-Layer Membrane Reactor for Heterogeneous and Homogeneous Catalytic Gas–Liquid Reactions,” Green Chemistry, (2018) DOI: 10.1039/c8gc01917g

P. Zhang, N. Weeranoppanant, D.A. Thomas, K. Tahara, T. Stelzer, M.G. Russell, M. O’Mahony, A.S. Myerson, H. Lin, L.P. Kelly, K.F. Jensen, T.F. Jamison, C. Dai, Y. Cui, N. Briggs, R.L. Beingessner, A. Adamo, “Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing,” Chem. Eur. J., 24, 1-10 (2018) DOI: 10.1002/chem.201706004

J. Imbrogno, L. Rogers, D.A. Thomas, K.F. Jensen, “Continuous Purification of Active Pharmaceutical Ingredients Utilizing Polymer Membrane Surface Wettability,” Chem. Comm., 54(1), 70-73 (2018) DOI: 10.1039/C7CC08218E

2017

2017

K. F. Jensen, “Flow chemistry—Microreaction technology comes of age,” AIChE J, 63, 858-867 (2017). DOI: 10.1002/aic.15642

M. Peer, M. Lusardi, and K.F. Jensen, “Facile soft-templated synthesis of high-surface area and highly porous carbon nitrides,” Chem Mater, 29 (4), 1496–1506 (2017) DOI: 10.1021/acs.chemmater.6b03570

A. Mijalis, D.A. Thomas, M.D. Simon, A. Adamo, R. Beaumont, K.F. Jensen, B.L. Pentelute, “Automated flow peptide synthesis: toward amide bonds at Nature’s pace,” Nature Chemical Biology, 13, 464–466 (2017). DOI: 10.1038/nchembio.2318

X. Ding, M. P. Stewart, A. Sharei, J.C. Weaver, R.S. Langer and K.F. Jensen, “High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption” Nature Biomed. Eng. 1, 0039 (2017). DOI: 10.1038/s41551-017-0039

O.T. Bruns, T.S. Bischof, D.K. Harris, D. Franke, Y. Shi, L. Riedemann, A. Bartelt, F.B. Jaworski, J.A. Carr, C.J. Rowlands, M.W.B. Wilson1, O. Chen, H. Wei, G.W. Hwang, D.M. Montana, I. Coropceanu, O.B. Achorn, J. Kloepper, J. Heeren, P.T.C. So, D. Fukumura, K.F. Jensen, R.K. Jain and M.G. Bawendi, “Next-generation in vivo optical imaging with short-wave infrared quantum dots,” Nature Biomed. Eng. 1, 0056 (2017). DOI: 10.1038/s41551-017-0056

N. Weeranoppanant, A. Adamo, G. Saparbaiuly, Eleanor Rose, Christian Fleury, Berthold Schenkel, and Klavs F. Jensen, “Design of multistage counter-current liquid−liquid extraction for small-scale applications,” Ind. Eng. Chem. 56 (14) 4095–4103 (2017). DOI: 10.1021/acs.iecr.7b00434

V. Sebastián, N. Zaborenko, L. Gu, and K.F. Jensen, “Microfluidic assisted synthesis of hybrid Au−Pd dumbbell-like nanostructures: Sequential addition of reagents and ultrasonic radiation,” Cryst. Growth Des. 17 (5), 2700–2710 (2017). DOI: 10.1021/acs.cgd.7b00193

C.W. Coley, R. Barzilay, T.S. Jaakkola, W.H. Green, and K.F. Jensen, “Prediction of organic reaction outcomes using machine learning,” ACS Cent. Sci. 3, 434−443 (2017). DOI: 10.1021/acscentsci.7b00064

Y. Shen, N. Weeranoppanant, L. Xie, Y. Chen, M.R. Lusardi, J. Imbrogno, M.G. Bawendi, and K.F. Jensen, “Multistage extraction platform for highly efficient and fully continuous purification of nanoparticles,” Nanoscale, 9, 7703-7 (2017). DOI: 10.1039/c7nr01826f

Y-J. Hwang, C.W. Coley, M.Abolhasani, A.L. Marzinzik, G. Koch, C. Spanka, H. Lehmann, and K.F. Jensen, “A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets,”Chem Commu., 53, 6649-52 (2017). DOI: 10.1039/c7cc03584e

J. Zhang, K. Wang, A.R. Teixeira, K.F. Jensen, and G. Luo, “Design and scaling up of microchemical systems: A Review,” Annu. Rev. Chem. Biomol. Eng. 8, 285–305 (2017). DOI: 10.1146/annurev-chembioeng-060816-101443

H. Lin, C. Dai, T.F. Jamison, K.F. Jensen, “A rapid total synthesis of ciprofloxacin hydrochloride in continuous flow,” Angew. Chem. Int. Ed. 56, 8870-8873 (2017). DOI: 10.1002/anie.201703812

C.W. Coley, M. Abolhasani, H. K Lin, K. F. Jensen, “Material-Efficient Microfluidic Platform for Exploratory Studies of Visible-Light Photoredox Catalysis,” Angew. Chem. Int. Ed. 56, 9847-9850 (2017). DOI: 10.1002/anie.201705148

S. Lazzari, M. Abolhasani, and K,F. Jensen, “Modeling of the formation kinetics and size distribution evolution of II–VI quantum dots,” React. Chem. Eng., 2, 567–576 (2017) DOI: 10.1039/c7re00068e

C.W. Coley, R. Barzilay, W.H. Green, T.S. Jaakkola, and KF. Jensen, “Convolutional Embedding of Attributed Molecular Graphs for Physical Property Prediction,” J. Chem. Inf. Model., 57 (8), 1757–1772 (2017) DOI: 10.1021/acs.jcim.6b00601

J. Zhang, A.R. Teixeira, L.T. Kögl, L. Yang, and K.F. Jensen, “Hydrodynamics of gas–liquid flow in micropacked beds: Pressure drop, liquid holdup, and two-phase model,” AIChE J., 63, 4694–4704 (2017). DOI: 10.1002/aic.15807

J. Zhang, A.R. Teixeira, H. Zhang, and K.F. Jensen, Anal. Chem., 89, 8524−8530 (2017). DOI: 10.1021/acs.analchem.7b02264

K. Lee, H. Lin and K.F. Jensen, “Ozonolysis of quinoline and quinoline derivatives in a Corning low flow reactor,” React Chem Eng, (2017) DOI: 10.1039/c7re00084g

J. Zhang, A.R. Teixeira, and K.F. Jensen. “Automated measurements of gas-liquid mass transfer in micropacked bed reactors,” AIChE J., (2017). DOI: 10.1002/aic.15941

2016

2016

V. Sebastian, S. Basak and K.F. Jensen, “Continuous synthesis of palladium nanorods in oxidative segmented flow.” 62 (2) 373-380 (2016). DOI 10.1002/aic.15029.

A. Kollmannsperger, A. Sharei, A. Raulf, M. Heilemann, R. Langer, K.F. Jensen, R. Wieneke, and R. Tampe, “Live-cell protein labeling with nanometer precision by cell squeezing,” Nature Comm 7, 10372 (2016). DOI: 10.1038/ncomms10372

L. Xie, Q. Zhao, K.F. Jensen, H. Kulik, “Direct Observation of Early-Stage Quantum Dot Growth Mechanisms with High-Temperature Ab Initio Molecular Dynamics” J. Phys. Chem. C, 120, 2472-2483 (2016). DOI: 10.1021/acs.jpcc.5b12091

V. Sebastian, C.D. Smith, and K.F. Jensen, “Shape-controlled continuous synthesis of metal nanostructures,“ Nanoscale, 8, 7534 – 7543 (2016). (2016), DOI: 10.1039/c5nr08531d.

J.S. Moore, C.D. Smith, and K.F. Jensen, “Kinetic Analysis and Automated Screening of Aminocarbonylation of Aryl Halides in Flow,” React Chem Eng, 1, 272-279 (2016). DOI: 10.1039/c6re00007j

A. Adamo, R.L. Beingessner, M. Behnam, J. Chen, T.F. Jamison, K.F. Jensen, J.-C. M. Monbaliu, A.S. Myerson, E.M. Revalor, D.R. Snead, T. Stelzer, N. Weeranoppanant, S.Y. Wong, P. Zhang (authors alphabetical order), “On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system,” Science, 352 (6281) 61-66 (2016). DOI:10.1126/science.aaf1337

A.E. Fernandes, O. Riant, A.M. Jonas and K.F. Jensen, “One “Click” to controlled bifunctional supported catalysts for the Cu/TEMPO-catalyzed aerobic oxidation of alcohols,” RSC Advances, 6, 36602 – 36605 (2016). DOI: 10.1039/c6ra05026c

J.-C. M. Monbaliu, T. Stelzer, E. Revalor, N. Weeranoppanant, K.F. Jensen, and A.S. Myerson, “Compact and integrated approach for advanced end-to-end production, purification, and aqueous formulation of lidocaine hydrochloride,” Org. Process Res. Dev. (2016). DOI: 10.1021/acs.oprd.6b00165

M. Abolhasani and K.F. Jensen, “Oscillatory multiphase flow strategy for chemistry and biology,“ Lab Chip, 16, 2775–2784 (2016). DOI: 10.1039/c6lc00728g

T.A. Shatova, S. Lathwal, M.R. Engle, H.D. Sikes, and K.F. Jensen, “Portable, constriction–expansion blood plasma separation and polymerization-based malaria detection,” Anal. Chem., 88 (15), pp 7627–7632 (2016). DOI: 10.1021/acs.analchem.6b01355

A.E. Fernandes, O. Riant, K.F. Jensen, A.M. Jonas, “Molecular engineering of trifunctional supported catalysts for the aerobic oxidation of alcohols,“ Angew. Chemie. Int. Ed. (2016). DOI: 10.1002/anie.201603673

B.J. Reizman and K.F. Jensen, “Feedback in flow for accelerated reaction development,” Acc. Chem. Res. 49, 1786−1796 (2016). DOI: 10.1021/acs.accounts.6b00261

M. Peer, N. Weeranoppanant, A. Adamo, Y. Zhang, and K.F. Jensen, “Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: scale-up and extraction,” Org. Process Res. Dev. 20 (9), 1677–1685 (2016). DOI: 10.1021/acs.oprd.6b00234

V. Sebastian and K.F. Jensen, “Nanoengineering a library of metallic nanostructures using a single microfluidic reactor,” Nanoscale, 8, 1528 8–15295 (2016). DOI: 10.1039/c6nr04104c

Y. Mo and K.F. Jensen, “A miniature CSTR cascade for continuous flow of reactions containing solids,” React Chem Eng, 1, 501-507(2016). DOI: 10.1039/c6re00132g

B.J. Reizman, Y.-M. Wang, S.L. Buchwald, and K.F. Jensen, “Suzuki–Miyaura cross-coupling optimization enabled by automated feedback,” React Chem Eng, 1, 658-666 (2016). DOI: 10.1039/c6re00153j

L. Xie, Y. Shen, D. Franke, V, Sebastián, M.G. Bawendi, and K. F. Jensen, “Characterization of indium phosphide quantum dot growth intermediates using MALDI-TOF Mass Spectrometry,” J. Am. Chem. Soc. 138 (41), 13469–13472 (2016). DOI: 10.1021/jacs.6b06468

M.T. Saung, A. Sharei, V.A. Adalsteinsson, N. Cho, T. Kamath, C. Ruiz, J. Kirkpatrick, N. Patel, M. Mino-Kenudson, S.P. Thayer, R.S. Langer, K.F. Jensen, A. S. Liss, and J.C. Love, “A size-selective intracellular delivery platform,” Small, 12 (42) 5873–5881 (2016). DOI: 10.1002/smll.201601155

M.P. Stewart, A. Sharei, X. Ding, G. Sahay, R.S. Langer, and K.F. Jensen, “In vitro and ex vivo strategies for intracellular delivery,” Nature 538, 183–192 (2016). DOI:10.1038/nature19764

L. Yang, M.J. Nieves-Remacha, K.F. Jensen, “Simulations and analysis of multiphase transport and reaction in segmented flow microreactors,” Chem. Eng. Sci. 169, 106–116 (2017). DOI: 10.1016/j.ces.2016.12.003

2015

2015

M.J. Nieves Remacha and K.F Jensen, “Mass Transfer Characteristics of Ozonolysis in Microreactors and Advanced-Flow Reactors,” J. Flow Chemistry, ASAP (2015) http://dx.doi.org/10.1556/1846.2015.00010

L. Xie, D.K. Harris, M.G. Bawendi, and K. F. Jensen, ”The effect of trace water on the growth of indium phosphide quantum dots,” Chem. Mater., 27 (14) 5058-5063 (2015) http://dx.doi.org/10.1021/acs.chemmater.5b01626

M.J. Nieves Remacha, A.A. Kulkarni, and K. F. Jensen, ”OpenFOAM computational fluid dynamic simulations of single phase flows in an Advanced-Flow Reactor,” Ind. Eng. Chem. Res., 54 (30) 7543-7553 (2015) http://dx.doi.org/10.1021/acs.iecr.5b00232

M. Abolhasani, C.W. Coley, L. Xie, O. Chen, M.G. Bawendi, and K.F. Jensen, ”Oscillatory Microprocessor for Growth and in-situ Characterization of Semiconductor Nanocrystals,” Chem. Mater., 27 (17) 6131–6138 (2015) http://dx.doi.org/10.1021/acs.chemmater.5b02821

D. Franke, D.K. Harris, L. Xie, K.F. Jensen, M.G. Bawendi, “The unexpected influence of precursor conversion rate for III-V quantum dots,” Angew. Chemie. Int. Ed., 54: 14299–14303 (2015) DOI:10.1002/anie.201505972

M. Abolhasani, C.W. Coley and K.F. Jensen, “Multi-Phase oscillatory flow strategy for in-situ measurement and screening of partition coefficients,” Anal. Chem., 87 (21) 11130–11136 (2015).

I.R. Baxendale, R.D. Braatz, B.K Hodnett, K.F. Jensen, M.D Johnson, P. Sharratt, J.-P. Sherlock, A.J. Florence, “Achieving continuous manufacturing: Technologies and approaches for synthesis, workup, and isolation of drug substance,” J. Pharm. Sci., 104 (3) 781-791 (2015). http://dx.doi.org/10.1002/jps.24252

S.G. Newman, K. Lee, J. Cai, L. Yang, W.H. Green, and K.F. Jensen, “Continuous thermal oxidation of alkenes with nitrous oxide in a packed bed reactor,” Ind. Eng. Chem. 54 (16), 4166–4173 (2015). http://dx.doi.org/10.1021/ie504129e

E.J. O’Neal, C.H. Lee, J. Brathwaite, and K.F. Jensen, “Continuous nanofiltration and recycle of an asymmetric ketone hydrogenation catalyst,” ACS Catal. 5, 2615−2622 (2015). http//dx.doi.org/10.1021/acscatal.5b00149

M. Abolhasani, N.C. Bruno and K.F. Jensen, “Oscillatory three-phase flow reactor for studies of bi-phasic catalytic reactions,” Chem. Commun., 51, 8916-8919 (2015). http//dx.doi.org/10.1039/C5CC02051D

A. Sharei, R. Trifonova, S. Jhunjhunwala, G.C. Hartoularos, A. Eyerman, A. Lytton-Jean, M. Angin, S. Sharma, R. Poceviciute, S. Mao, M. Heimann, S. Liu, T. Talkar, O.F Khan, M. Addo, U.H. von Andrian, D.G. Anderson, R.S. Langer, J. Lieberman, K.F. Jensen, “Ex vivo cytosolic delivery of functional macromolecules to immune cells,” PLoS ONE 10(4): e0118803. (2015). http//dx.doi.org/10.1371/journal.pone.0118803

L. Yang, Y. Shi, M. Abolhasani and K.F. Jensen, “Characterization and modeling of multiphase flow in structured microreactors: a post microreactor case study,” Lab Chip, 15, 3232-3241 (2015) http://dx.doi.org/10.1039/C5LC00431D

G.L. Szeto, D.V. Egeren, H. Work, A. Sharei, B. Alejandro, C. Park, K. Frew, M. Brefo, S. Mao, M. Heimann, R..S. Langer, K.F. Jensen, and D.J. Irvine, “Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines,” Scientific Reports, 5:10276 (2015). http//dx.doi.org/10.1038/srep10276

M.J. Nieves Remacha, L. Yang, and K.F Jensen, “OpenFOAM computational fluid dynamic simulations of two-phase flow and mass transfer in an Advanced-Flow Reactor,” Ind.Eng.Chem.Res. ASAP 2015. http//dx.doi.org/10.1021/acs.iecr.5b00480

B.J. Reizman and K.F. Jensen, “Simultaneous solvent screening and reaction optimization in microliter slugs,” Chem. Commun., 51, 13290-13293 (2015). http://dx.doi.org/10.1039/C5CC03651H

M.J. Nieves Remacha and K.F Jensen, “Mass Transfer Characteristics of Ozonolysis in Microreactors and Advanced-Flow Reactors,” J. Flow Chemistry, ASAP (2015) http://dx.doi.org/10.1556/1846.2015.00010

L. Xie†, D.K. Harris, M.G. Bawendi, and K. F. Jensen, ”The effect of trace water on the growth of indium phosphide quantum dots,” Chem. Mater., ASAP (2015) http://dx.doi.org/10.1021/acs.chemmater.5b01626

M.J. Nieves Remacha, A.A. Kulkarni, and K. F. Jensen, ”OpenFOAM computational fluid dynamic simulations of single phase flows in an Advanced-Flow Reactor,” Ind. Eng. Chem. Res., ASAP (2015) http://dx.doi.org/10.1021/acs.iecr.5b00232

M. Abolhasani, C.W. Coley, L. Xie, O. Chen, M.G. Bawendi, and K.F. Jensen, ”Oscillatory Microprocessor for Growth and in-situ Characterization of Semiconductor Nanocrystals,” Chem. Mater., ASAP (2015) http://dx.doi.org/10.1021/acs.chemmater.5b02821

2014

2014

K.F. Jensen, B.J. Reizman and S.G. Newman, “Tools for chemical synthesis in microsystems,” Lab Chip, 14, 3206-3212 (2014). http://dx.doi.org/10.1039/c4lc00330f

S.D. Schaber, S.C. Born, K.F. Jensen, and P.I. Barton, “Design, execution, and analysis of time-varying experiments for model discrimination and parameter estimation in microreactors,” Org. Process Res. Dev., 18, 1461−1467 (2014). http://dx.doi.org/10.1021/op500179r

E.J. O’Neal and K.F. Jensen, “Continuous nanofiltration and recycle of a metathesis catalyst in a microflow system,” ChemCatChem, 6, 3004 – 3011 (2014). http://dx.doi.org/10.1002/cctc.201402368

Y. Zhang, S.C. Born, and K.F. Jensen, “Scale-up investigation of the continuous phase-transfer-catalyzed hypochlorite oxidation of alcohols and aldehydes,” Org. Process Res. Dev., 18, 1476−1481 (2014). http://dx.doi.org/10.1021/op500158h

V. Sebastian, S.-K. Lee, and K.F. Jensen, “Engineering the synthesis of silica–gold nano-urchin particles using continuous synthesis,” Nanoscale, 6, 13228–13235 (2014). http://dx.doi.org/10.1039/c4nr04021j

A.R.C. Duarte, B. Ünal, J.F. Mano, R.L. Reis, and K.F. Jensen, “Microfluidic production of perfluorocarbon-alginate core−shell microparticles for ultrasound therapeutic applications,” Langmuir, 30, 12391−12399 (2014). http://dx.doi.org/10.1021/la502822v

N. Heublein, J.S. Moore, C.D. Smith and K.F. Jensen, “Investigation of Petasis and Ugi reactions in series in an automated microreactor system,” RSC Adv., 4, 63627-63631 (2014). http://dx.doi.org/10.1039/c4ra13626h

Duarte, A. R. C., Ünal, B., Mano, J. F., Reis, R. L., & Jensen, K. F. (2014). Microfluidic Production of Perfluorocarbon-Alginate Core–Shell Microparticles for Ultrasound Therapeutic Applications. Langmuir, 30(41), 12391-12399. DOI: 10.1021/la502822v

O’Neal, E. J., & Jensen, K. F. (2014). Continuous Nanofiltration and Recycle of a Metathesis Catalyst in a Microflow System. ChemCatChem, 6(10), 3004-3011. DOI: 10.1002/cctc.201402368

Zhang, Y., Born, S. C., & Jensen, K. F. (2014). Scale-Up Investigation of the Continuous Phase-Transfer-Catalyzed Hypochlorite Oxidation of Alcohols and Aldehydes. Organic Process Research & Development. DOI: 10.1021/op500158h

Schaber, S. D., Born, S., Jensen, K. F., & Barton, P. I. (2014). Design, execution, and analysis of time-varying experiments for model discrimination and parameter estimation in microreactors. Organic Process Research & Development. DOI: 10.1021/op500179r

Woitalka, A., Kuhn, S., & Jensen, K. F. (2014). Scalability of mass transfer in liquid–liquid flow. Chemical Engineering Science, 116, 1-8.

Zhang, H., Lakerveld, R., Heider, P. L., Tao, M., Su, M., Testa, C. J., … & Evans, J. M. (2014). Application of continuous crystallization in an integrated continuous pharmaceutical pilot plant. Crystal Growth & Design, 14(5), 2148-2157. DOI: 10.1021/cg401571h

Sharei, A., Poceviciute, R., Jackson, E. L., Cho, N., Mao, S., Hartoularos, G. C., … & Jensen, K. F. (2014). Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform. Integr. Biol., 6(4), 470-475. DOI: 10.1039/C3IB40215K

Simon, M. D., Heider, P. L., Adamo, A., Vinogradov, A. A., Mong, S. K., Li, X., … & Pentelute, B. L. (2014). Rapid Flow‐Based Peptide Synthesis. ChemBioChem, 15(5), 713-720. DOI: 10.1002/cbic.201300796

de Mas, N., Schmidt, M. A., & Jensen, K. F. (2014). Nested potassium hydroxide etching and protective coatings for silicon-based microreactors.Journal of Micromechanics and Microengineering, 24(3), 035011.

Heider, P. L., Born, S. C., Basak, S., Benyahia, B., Lakerveld, R., Zhang, H., … & Jensen, K. F. (2014). Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical. Organic Process Research & Development, 18(3), 402-409. DOI: 10.1021/op400294z

Lee, S. K., Baek, J., & Jensen, K. F. (2014). High Throughput Synthesis of Uniform Biocompatible Polymer Beads with High Quantum Dot Loading Using Microfluidic Jet-Mode Breakup. Langmuir, 30(8), 2216-2222. DOI: 10.1021/la4041198

Neuenschwander, U., & Jensen, K. F. (2014). Olefin Autoxidation in Flow. Industrial & Engineering Chemistry Research, 53(2), 601-608. DOI: 10.1021/ie402736j

Moore, J. S., & Jensen, K. F. (2014). “Batch” Kinetics in Flow: Online IR Analysis and Continuous Control. Angewandte Chemie, 126(2), 480-483. DOI: 10.1002/ange.201306468

Newman, S. G., Gu, L., Lesniak, C., Victor, G., Meschke, F., Abahmane, L., & Jensen, K. F. (2014). Rapid Wolff–Kishner reductions in a silicon carbide microreactor. Green Chemistry, 16(1), 176-180. DOI: 10.1039/C3GC41942H

2013

2013

Mascia, S., Heider, P. L., Zhang, H., Lakerveld, R., Benyahia, B., Barton, P. I., Braatz, R. D., Cooney, C. L., Evans, J. M. B., Jamison, T. F., Jensen, K. F., Myerson, A. S. and Trout, B. L. (2013), End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation. Angew. Chem. Int. Ed., 52: 12359–12363. http://dx.doi.org/10.1002/anie.201305429

Castro, F., Kuhn, S., Jensen, K., Ferreira, A., Rocha, F., Vicente, A., & Teixeira, J. A. (2013). Process intensification and optimization for hydroxyapatite nanoparticles production. Chemical Engineering Science, 10, 352-359. http://dx.doi.org/10.1016/j.ces.2013.01.002

Adamo, A., Heider, P. L., Weeranoppanant, N., & Jensen, K. F. (2013). Membrane-Based, Liquid–Liquid Separator with Integrated Pressure Control.Industrial & Engineering Chemistry Research, 52(31), 10802-10808. http://dx.doi.org/10.1021/ie401180t

Li, P., Moore, J. S., & Jensen, K. F. (2013). A Microfluidic System for the Continuous Recycling of Unmodified Homogeneous Palladium Catalysts through Liquid/Liquid Phase Separation. ChemCatChem, 5(7), 1729-1733.
http://dx.doi.org/10.1002/cctc.201300054

Nieves-Remacha, M. J., Kulkarni, A. A., & Jensen, K. F. (2013). Gas–Liquid Flow and Mass Transfer in an Advanced-Flow Reactor. Industrial & Engineering Chemistry Research, 52(26), 8996-9010.
http://dx.doi.org/10.1021/ie4011707

Yang, L., & Jensen, K. F. (2013). Mass Transport and Reactions in the Tube-in-Tube Reactor. Organic Process Research & Development, 17(6), 927-933.
http://dx.doi.org/10.1021/op400085a

Neuenschwander, U., Negron, A., & Jensen, K. F. (2013). A Clock Reaction Based on Molybdenum Blue. The Journal of Physical Chemistry A, 117(21), 4343-4351.
http://dx.doi.org/10.1021/jp400879d

Chan, W. R., Bermel, P., Pilawa-Podgurski, R. C., Marton, C. H., Jensen, K. F., Senkevich, J. J., … & Celanovic, I. (2013). Toward high-energy-density, high-efficiency, and moderate-temperature chip-scale thermophotovoltaics.Proceedings of the National Academy of Sciences, 110(14), 5309-5314. http://www.pnas.org/content/110/14/5309.short

Liu, X., & Jensen, K. F. (2013). Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants. Green Chemistry, 15(6), 1538-1541. http://pubs.rsc.org/EN/content/articlelanding/2013/gc/c3gc40407b#!divAbstract

Newman, Stephen G., and Klavs F. Jensen. “The role of flow in green chemistry and engineering.” Green Chemistry 15.6 (2013): 1456-1472.
http://pubs.rsc.org/en/content/articlehtml/2013/gc/c3gc40374b

Adamo, A., Arione, A., Sharei, A., & Jensen, K. F. (2013). Flow-through comb electroporation device for delivery of macromolecules. Analytical chemistry,85(3), 1637-1641.
http://pubs.acs.org/doi/abs/10.1021/ac302887a

Rinnerbauer, V., Ndao, S., Yeng, Y. X., Senkevich, J. J., Jensen, K. F., Joannopoulos, J. D., … & Geil, R. D. (2013). Large-area fabrication of high aspect ratio tantalum photonic crystals for high-temperature selective emitters.Journal of Vacuum Science & Technology B, 31(1), 011802. http://scitation.aip.org/content/avs/journal/jvstb/31/1/10.1116/1.4771901

V. Rinnerbauer, S. Ndao, Y. Xiang Yeng, J.J. Senkevich, K.F. Jensen, J.D. Joannopoulos, M. Soljacic, and I. Celanovic, “Large-area fabrication of high aspect ratio tantalum photonic crystals for high-temperature selective emitters” J. Vac. Sci. Technol. B 31(1), Jan/Feb 2013 http://dx.doi.org/10.1116/1.4771901

A. Adamo, A. Arione, A. Sharei, and K.F. Jensen, “Flow through comb electroporation device for delivery of macromolecules” Anal. Chem, 85, 1637–1641 (2013) http://dx.doi.org/10.1021/ac302887a

A. Sharei, J. Zoldan, A.Adamoa, W.Y. Sim, Na. Cho, E. Jackson, S. Mao, S. Schneider, M.-J. Han, A. Lytton-Jean, P. A. Basto, S. Jhunjhunwala, J. Lee, D.A. Heller, J. W. Kang, G.C. Hartoularos, K. S. Kim, D.G. Anderson, R.S. Langer, and K. F. Jensen, “A vector-free microfluidic platform for intracellular delivery” PNAS http://www.pnas.org/content/early/2013/01/16/1218705110 (2013)

A. Adamo, O. Roushdy, R. Dokov, A .Sharei1 and K. F. Jensen, “Microfluidic jet injection for delivery into cells,” J. Micromechanics Microengineering 23 (2013) 035026. http://stacks.iop.org/JMM/23/035026

2012

2012

E.V. Dydek, M.V. Petersen, D.G. Nocera and K.F. Jensen, “Realization of a salt bridge-free microfluidic reference electrode,” Lab Chip 12, 1431-33 (2012) http://dx.doi.org/10.1039/c2lc21195e

X. Liu and K.F. Jensen, “Direct oxidative amidation of aromatic aldehydes using aqueous hydrogen peroxide in continuous flow microreactor systems,” Green Chemistry 14 (5), 1471 – 1474 (2012). http://dx.doi.org/10.1039/c2gc35078e

V. Sebastian Cabeza, S. Kuhn, A.A. Kulkarni, and K.F. Jensen, “Size-controlled flow synthesis of gold nanoparticles using a segmented flow microfluidic platform,” Langmuir, 28 (17), 7007–7013 (2012) http://dx.doi.org/10.1021/la205131e

V. Sebastian Cabeza, S.-K. Lee, C. Zhou, M.F. Kraus, J.G. Fujimoto and K.F. Jensen, “One-step continuous synthesis of biocompatible gold nanorods for optical coherence tomography,” Chem. Commun., 48, 6654–6656 (2012). http://dx.doi.org/10.1039/C2CC32969G

S. Kuhn and Klavs F. Jensen, “A pH-sensitive laser-induced fluorescence technique to monitor mass transfer in multiphase flows in microfluidic devices,” Ind. Eng. Chem. Res., 51 (26), 8999–9006 (2012) http://dx.doi.org/10.1021/ie300978n

A. Adamo, A. Sharei, L. Adamo, B.-K. Lee, S. Mao, and K.F. Jensen, “Microfluidics-based assessment of cell deformability,” Anal. Chem., 84, 6438−6443 (2012). http://dx.doi.org/10.1021/ac300264v

J.S. Moore and K.F. Jensen, “Automated multitrajectory method for reaction optimization in a microfluidic system using online IR analysis,” Org. Process Res. Dev., 16 (8), 1409–1415 (2012). http://dx.doi.org/10.1021/op300099x

S.-K. Lee, X.g Liu, V. Sebastian Cabeza, and K.F. Jensen, “Synthesis, assembly and reaction of a nanocatalyst in microfluidic systems: a general platform,” Lab Chip, 12, 4080-4084 (2012) http://dx.doi.org/10.1039/c2lc40186j

X. Liu, B. Ünal, and K. F. Jensen, “Heterogeneous catalysis with continuous flow microreactors,” Catal. Sci. Technol., 2, 2134-2138 (2012) http://dx.doi.org/10.1039/c2cy20260c.

E.V. Dydek, M.V. Petersen, D.G. Nocera, and K.F. Jensen, “Electrode placement and fluid flow rates in microfluidic electrochemical devices,” J. Electrochem. Soc. 159 (11), H853-H856 (2012). http://dx.doi.org/10.1149/2.007211jes

B.J. Reizman, K.F. Jensen, “An Automated Continuous-Flow Platform for the Estimation of Multistep Reaction Kinetics,” Org. Process Res. Dev., 16 (11) 1673-1876 (2012). http://dx.doi.org/10.1021/op3001838

M. Sultana, K.F. Jensen, “Microfluidic Continuous Seeded Crystallization: Extraction of Growth Kinetics and Impact of Impurity on Morphology,” Cryst. Growth Design, 16 (11) 1673-1876 (2012). http://dx.doi.org/10.1021/cg301538y

J. Lee, A. Sharei, W.Y. Sim, A. Adamo, R. Langer, K.F. Jensen, and M.G. Bawendi, “Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device,” Nano Lett., 12(12) 6322–6327 (2012). http://dx.doi.org/10.1021/nl303421h

M.J. Nieves Remacha, A.A. Kulkarni, K.F. Jensen, “Hydrodynamics of Liquid-Liquid Dispersion in an Advanced-Flow Reactor,” Ind. Eng. Chem. Res., 51(50), 16251–16262 (2012). http://dx.doi.org/10.1021/ie301821k

2011

2011

J. Keybl and K. F. Jensen, “Microreactor system for high-pressure continuous flow homogeneous catalysis measurements,” 50 (19) 11013–11022 (2011). http://dx.doi.org/10.1021/ie200936b

K.D. Nagy and K.F. Jensen, “Catalytic processes in small scale flow reactors: Status and opportunities,” chimica oggi/Chemistry Today, 29 (4) (2011).

L. Chao, F. Chen, K.F. Jensen, and T.A. Hatton, Langmuir, 27 (16) 10050–10060 (2011). http://dx.doi.org/10.1021/la2015836

K. Pimparkar, B. Yen1, J. R. Goodell, V.I. Martin, W.-H. Lee, J.A. Porco, Jr., A.B. Beeler, and K.F. Jensen, “Development of a photochemical microfluidics platform,” Journal of Flow Chemistry 1 (2) (2011). http://dx.doi.org/ 10.1556/jfchem.2011.00006

C.H. Marton, G.S. Haldeman, and K.F. Jensen, “Portable thermoelectric power generator based on a microfabricated silicon combustor with low resistance to flow,” Ind. Eng. Chem. Res. 50 (14) 8468–8475 (2011). http://dx.doi.org/10.1021/ie200210d

R.L. Hartman, J.P. McMullen, and K.F. Jensen, “Deciding whether to go with the flow – evaluating the merits of flow reactors for synthesis,” Angew Chemie Int. Ed. Angew Chemie Int. Ed., 50, 7502-7519 (2011). http://dx.doi.org/10.1002/anie.201004637

S. Kuhn, T. Noël, L. Gu and K.F. Jensen, A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions, Lab on a Chip, 11 2488 – 2492 (2011). http://dx.doi.org/10.1039/c1lc20337a

T. Noël, S. Kuhn, A. J. Musacchio, K. F. Jensen and S. L. Buchwald, “Suzuki–Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction,“ Angew Chemie Int. Ed., 50, 5943 –5946 (2011). http://dx.doi.org/10.1002/anie.201101480

S. Kuhn, R.L. Hartman, M. Sultana, K.D. Nagy, S. Marre, and K.F. Jensen, “Teflon-Coated Silicon Microreactors: Impact on segmented liquid multiphase flows,” Langmuir 27, 6519–6527 (2011) http://dx.doi.org/10.1021/la2004744

J.P. McMullen and K.F. Jensen, “Determination of reaction kinetics with an automated microfluidic system,” Org. Process Res. Dev., 15 398–407 (2011) . http://dx.doi.org/10.1021/op100300p

T. Noël, J. R. Naber, R. L. Hartman, J. P. McMullen, K. F. Jensen and S. L. Buchwald, “Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation,” Chemical Sciences (RSC), Chem. Sci., 2, 287-290, (2011), http://dx.doi.org/10.1039/C0SC00524J

J. Baek, P.M. Allen, M. G. Bawendi, and K. F. Jensen, “Investigation of InP nanocrystal synthesis using a high-temperature and high-pressure continuous flow microreactor,” Angew Chemie Int. Ed., http://dx.doi.org/10.1002/anie.201006412

N. Zaborenko, M.W. Bedore, T. F. Jamison, and K. F. Jensen, “Kinetic and scale-up investigations of epoxide aminolysis in microreactors at high temperatures and pressures,” Org. Process Res. Dev., 15, 131–139 (2011) http://dx.doi.org/10.1021/op100252m